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Week 4 NFL score predictions, odds, picks, betting advice: Computer model locks in projections for every game

As the fourth week of professional football gets underway, a sophisticated computer simulation has simulated every upcoming matchup ten thousand times to generate projections and wagering advice. Among the slate of games, an undefeated divisional showdown features Kansas City hosting the Raiders, with oddsmakers installing the visitors as underdogs by 4.5 points and a total line resting at 47.5.

Meanwhile, the Rams visit Philadelphia for a contest between struggling squads, with Los Angeles favored by three points and an over/under set at 42.5.

Several key roster absences impact Sunday's action across the league. Los Angeles will be missing defensive lineman Aaron Donald due to a back issue, though wide receiver Puka Nacua is cleared to play despite hip and groin concerns.

Additional inactives include running back Breece Hall for the Jets, quarterback Baker Mayfield dealing with a thumb injury for Tampa Bay, and wide receiver DeVonta Smith sidelined with a hamstring problem for the Eagles.

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