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Week 1 betting: Odds, lines and totals for every game

The 2026 NFL campaign has commenced, following an opening slate that saw Seattle edge New England 13-10 on Wednesday before San Francisco secured a comfortable win against the Rams on Thursday in Australia. An extensive 13-game schedule awaits on Sunday, highlighted by a narrow line favoring Buffalo over Houston in the early afternoon, while Dallas enters their classic divisional road test against the Giants favored by three points.

5 against Arizona. 5 total) as favorites according to DraftKings odds.

5 points.