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Texas Tech vs Colorado Prediction, Pick, College Football Odds for Saturday, Oct. 3

The Texas Tech Red Raiders prepare for a matchup against the Colorado Buffaloes at Folsom Field, with kickoff scheduled for 7:30 p.m. ET on FOX.

Texas Tech enters as a 13.5-point favorite with a 50.5-point over/under and a moneyline of -535, while Colorado sits as a 13.5-point underdog with a moneyline of +400. Colorado returns to Boulder for its home opener against an FBS opponent following consecutive road defeats, turning to Isaac Wilson at quarterback after he replaced JuJu Lewis last week.

Under offensive coordinator Brennan Marion, the Buffaloes lean on outside targets like Joseph Williams and a developing Go-Go running scheme.

On the other side, Texas Tech is trying to find stability under center with Will Hammond after stumbling through recent contests against Oregon State, Houston, and Sam Houston. The Red Raiders defense has experienced a sharp decline after sending six players to the NFL draft, losing the pass rush potency that once anchored their secondary.

This matchup offers Colorado an opportunity to cover the spread at home against an opponent facing major roster adjustments on both sides of the ball.

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