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Survey: Will the Lions beat the Bills in Week 2?

The Buffalo Bills are scheduled to host the Detroit Lions for a Week 2 matchup on Thursday Night Football, marking the regular-season unveiling of the franchise's new Highmark Stadium. Buffalo enters the contest favored over visiting Detroit as both franchises pursue their first Super Bowl title in franchise history.

Detroit heads on the road following an opening-week collapse where they relinquished a 21-point advantage, raising scrutiny around their potential this season. Buffalo quarterback Josh Allen presents a major hurdle for the Lions, while contributors such as Isaac TeSlaa have been targeted as pivotal factors if the road underdogs hope to secure a victory.