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Sean McVay and Rams W-L record following 49ers loss

The Los Angeles Rams opened their 2026 campaign with a 27-7 division defeat against the San Francisco 49ers, leaving Sean McVay's squad alone at the bottom of the NFC West as the group's only winless roster. Historically under McVay, Los Angeles has dropped consecutive games to launch a season just once, though the head coach acknowledged experiencing overwhelming stress after the opener.

On the field, quarterback Matthew Stafford struggled alongside the rest of the unit, while defensive back Quentin Lake recorded an interception and broke up two passes despite surrendering seven receptions on ten balls thrown his way.

Injuries have further complicated the team's immediate outlook heading into matchups with upcoming opponents like the Giants and Cardinals. Pass rusher Myles Garrett is currently out of action following knee surgery, forcing McVay to rely on two depth options to elevate their play, while Aaron Donald's availability for Week 2 remains uncertain.