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Rams-Giants Week 2 opening odds

Heading into a Week 2 Monday Night Football matchup against the New York Giants, the Los Angeles Rams have suffered a major blow on defense. Defensive end Myles Garrett must undergo knee surgery and will be placed on injured reserve, sidelining him for at least four weeks during a grueling stretch that also features dates with the Denver Broncos and Buffalo Bills.

This news compounds a rough start for Los Angeles, who opened the campaign with a lopsided defeat against the San Francisco 49ers in Australia, while questions also linger regarding Aaron Donald's playing status.

Meanwhile, the Giants are preparing to welcome back key playmaker Malik Nabers a week ahead of their clash with the Rams. New York enters that contest after opening their season against the Dallas Cowboys on Sunday Night Football, where they lean on stars like Daniel Jones and Dexter Lawrence.