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Penn State vs Northwestern Prediction, Pick, College Football Odds for Friday, October 2

The Penn State Nittany Lions and Northwestern Wildcats prepare to face off on Friday, October 2, with kickoff scheduled for 8 p.m. Eastern Time on FOX.

Penn State enters as a 2.5-point favorite and a 140-dollar moneyline choice, while Northwestern is set as the underdog at plus 2.5 points and plus 116 on the moneyline, with an over-under total of 45.5 points. Penn State coach Matt Campbell looks to rebound following a tough loss to Wisconsin, where quarterback Rocco Becht struggled in the passing game after losing receiver Koby Howard.

Meanwhile, Northwestern coach David Braun hopes to build on a previous cover led by quarterback Aidan Chiles, targets like Luke Dehnicke and Griffin Wilde, and an offense coordinated by Chip Kelly.

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