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Patriots vs. Bills odds, picks, prediction, spread: NFL Week 4 start time, betting preview and best bets

New England quarterback Drake Maye and his squad prepare for a critical divisional matchup against Buffalo this Sunday. The betting market establishes the home team as seven-point favorites with a total points projection resting at forty-nine and a half.

Buffalo enters the contest displaying a high-powered attack led by a dual-threat signal caller alongside running back James Cook III. The offense features primary targets Dalton Kincaid, DJ Moore, and Keon Coleman driving their unit deep into the early portion of the campaign.

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