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Patrick Mahomes is no stranger to Colts DC Lou Anarumo

Ahead of their Week 2 Sunday Night Football clash, the Indianapolis Colts are preparing to face familiar adversary Patrick Mahomes and the Kansas City Chiefs. Kansas City enters the game following a dominant Monday night victory over the Denver Broncos to kick off the regular season, while Indianapolis aims to bounce back from a heavy Week 1 defeat.

The Chiefs showcased a revamped offensive attack in their opener, featuring Kenneth Walker III, who amassed a personal-best 173 rushing yards against Denver. Mahomes also demonstrated his customary form despite returning from surgery on his left knee ligaments, presenting a stern challenge for Colts defensive coordinator Lou Anarumo.