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Opening odds see Bills looking to make a statement vs. Lions in Week 2

Early betting lines are set as the Buffalo Bills prepare to host the Detroit Lions for a Week 2 Thursday Night Football clash marking the inaugural regular-season contest at the new Highmark Stadium. Both squads enter the short week following tense offensive shootouts in their 2026 season openers, where Buffalo overcame the Houston Texans behind a record-setting game-winning drive orchestrated by Josh Allen, and Detroit narrowly survived against the New Orleans Saints.

The matchup offers a swift turnaround for a struggling Detroit pass defense that surrendered 410 passing yards to Tyler Shough after letting a 21-point advantage slip away against New Orleans. Quarterback Jared Goff and the Lions now face Allen's offense on just four days of rest, in a high-profile rematch after the two playcallers previously went head-to-head during Buffalo's 48-42 triumph at Ford Field back on December 15, 2024.