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NFL Week 6 betting: 5 biggest storylines, including how Rams upset loss shook up the odds

The Los Angeles Rams' stunning 12.5-point underdog loss to the Arizona Cardinals in Week 6 sent shockwaves through the NFL betting landscape, marking just the third time this season a team favored by that margin or more has fallen. The upset reshaped the Rams' standing in both the upcoming matchup and the Super Bowl futures, dropping them from near-elite contenders to fifth in the odds after a 2-4 start.

Their Week 7 line against the Las Vegas Raiders collapsed from a pre-game favorite by 7 points to just 4.5 points, reflecting waning confidence in their offense and defense following the Cardinals' upset. Meanwhile, the Rams' quarterback, Matthew Stafford, now faces a tougher path to a title bid as the team's struggles mount, while the league's winless against the spread, the Los Angeles Chargers, remain a betting anomaly despite their bye week.

Elsewhere, a tight race for MVP has emerged between Josh Allen and Brock Purdy, with both quarterbacks leading the odds after strong recent performances.

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