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NFL Week 2 odds: Seahawks open as heavy favorites vs. Cardinals

Early betting lines establish the Seattle Seahawks as commanding road favorites against the Arizona Cardinals for their upcoming Week 2 NFC West showdown. Nevertheless, the matchup presents new hurdles after Arizona pulled off a startling 26-14 triumph over the Los Angeles Chargers during opening week.

That unexpected result has quickly complicated expectations for Seattle's upcoming visit.

Adding further intrigue to the divisional clash are mounting physical setbacks across the division. Seattle faces uncertainty under center after quarterback Sam Darnold sustained a glute injury in Week 1, clouding his status with an ambiguous recovery timeline that may keep him sidelined beyond a single week.

The NFC West landscape was further rattled by an injury to Los Angeles Rams defensive standout Myles Garrett, shifting divisional dynamics right as the Cardinals prepare for their home opener.