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NFL Week 1 odds: Monday Night Football picks for Broncos vs. Chiefs

Week 1 of the 2026 NFL regular season concludes on Monday Night Football as the Denver Broncos head to Arrowhead Stadium to take on the Kansas City Chiefs. The divisional clash marks the initial instance of Denver beginning its campaign away from home against Kansas City, with the victor positioned to share the top spot in the AFC West alongside the victorious Las Vegas Raiders following an opening defeat by the Los Angeles Chargers.

The matchup also features signal-callers Patrick Mahomes and Bo Nix making their returns to action after both sustained substantial late-season injuries a year ago.

This final contest caps an expansive opening week across the league that featured an initial duel between the New England Patriots and Seattle Seahawks, an international showdown in Melbourne pitting the San Francisco 49ers against the Los Angeles Rams, and a Sunday night meeting contested by the Dallas Cowboys and New York Giants.