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NFL odds, betting, storylines: 3 underdogs to back in Week 1

Ahead of the opening weekend of the 2026 NFL campaign, the Jacksonville Jaguars prepare to host the Cleveland Browns at EverBank Stadium as heavy 8.5-point favorites. Jacksonville approaches the opener following a 13-4 record and an AFC South crown in the previous season.

Cleveland begins a fresh era under Todd Monken, who rolls out a lineup packed with rookies under the warm Florida sun. While quarterback Deshaun Watson faces unusually low statistical passing expectations, he aims to maintain his spotless career mark against the Jaguars despite an unsettled quarterback situation in Cleveland.