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Make your Week 2 NFL picks

Heading into Week 2 of the 2026 NFL campaign, the Los Angeles Rams remain favored to defeat the New York Giants on Monday night despite a turbulent start to their year. Los Angeles dropped its opener to the San Francisco 49ers in Australia and will be without defensive standout Myles Garrett, who is bound for injured reserve following knee surgery.

Rams signal-caller Matthew Stafford has already acknowledged the challenge ahead, labeling New York a serious threat after quarterback Jaxson Dart guided the squad to an unexpected home victory over the Dallas Cowboys on Sunday night by emulating Brock Purdy's offensive style.

Even though oddsmakers initially pegged New York as substantial underdogs in Los Angeles, the matchup promises to be much tighter than anticipated. These franchises last clashed on December 31, 2023, when the Rams narrowly secured a 26-25 triumph at MetLife Stadium despite Stafford enduring sacks from Kayvon Thibodeaux and Jihad Ward.

With Sean McVay addressing roster concerns such as Aaron Donald's status, the Rams must regroup quickly to avoid an early 0-2 deficit.