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Giants at Rams Week 2 opening odds: Giants open as big underdogs

Ahead of their Week 2 Monday Night Football clash, early betting lines peg the New York Giants as substantial underdogs against the Los Angeles Rams. Los Angeles opened its regular season on Thursday with a 27-7 blowout loss to the San Francisco 49ers in Australia, though head coach Sean McVay stressed that the defeat will not define the squad.

Making matters worse for the Rams, prized offseason addition Myles Garrett is headed for surgery and an injured reserve stint after his team debut, forcing him to miss at least four contests during a demanding slate that features the Bills and Broncos.

Meanwhile, the Giants enter the upcoming contest with significant roster momentum after silencing Dallas hype in Week 1, overcoming projections where pundits heavily favored the Cowboys. New York will not have to deal with Garrett and is also welcoming back standout Malik Nabers just one week prior to the Rams matchup.

As the Rams prepare without their $208 million defensive lineman, questions also surround Aaron Donald's Week 2 outlook.