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Everything to know for betting NFL Week 2, odds: Sharp action, public betting splits and big bets

Week 2 of the 2026 NFL campaign launched with a milestone matchup at the brand-new Highmark Stadium, where the Buffalo Bills secured a Thursday night triumph over the Detroit Lions. Meanwhile, the Chicago Bears prepare to host the Minnesota Vikings at Soldier Field, with quarterback Caleb Williams entering his third professional campaign under newly appointed head coach Ben Johnson following a dominant 59-point performance against Carolina.

Elsewhere across the league, the Los Angeles Rams prevailed in their prime-time battle against the New York Giants. Additional sports developments include the Los Angeles Dodgers securing the National League West title, while North Carolina defensive coordinator Belichick stepped down from his coaching post.