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Everything to know for betting NFL Week 1, odds: Sharp action, public betting splits and big bets

NFL Week 1 action brings a heavy slate of marquee matchups and intriguing betting storylines. 5 points while the Packers deal with key absences on both sides of the ball, including running back Josh Jacobs.

Elsewhere, Patrick Mahomes makes his anticipated return as the Denver Broncos attempt to spoil the Kansas City Chiefs' opener, and the Dallas Cowboys square off against the New York Giants in a closely debated division rivalry.

Key storylines also highlight a quarterback battle featuring Baker Mayfield against Joe Burrow, alongside a difficult road test for Josh Allen and the Buffalo Bills at Houston. Despite Vegas installing Buffalo as the favorite against the Texans, the Bills enter NRG Stadium burdened by a six-game skid at the venue.