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Dolphins offer 49ers a chance to build on their most surprising Week 1 strength

Following a decisive victory over the Los Angeles Rams in Australia, the San Francisco 49ers enter Week 2 sitting atop the NFC West. The commanding divisional rout, driven by quarterback Brock Purdy, wide receiver Mike Evans, and a suffocating defense, caused San Francisco's standing to soar in national power rankings and divisional odds.

Bookmakers have responded by making the 49ers nearly two-touchdown favorites for their next matchup, representing the widest projected margin of victory across the entire league for the week.

Their upcoming opponents, the Miami Dolphins, are trending in the opposite direction after tumbling to 31st in weekly rankings. Miami began the 2026 campaign with a 27-13 defeat against the Las Vegas Raiders, a contest marred by inconsistent quarterback play from Willis and an absent defensive line.

Coming off that double-digit loss, the Dolphins now travel as heavy underdogs against a surging San Francisco squad.