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This clash marks the fourth straight year Indianapolis has staged its opening game on home turf. While Indianapolis holds a 9-6 advantage over Baltimore in their historical regular-season meetings, consensus among analysts heavily favors the visiting squad to prevail in this Week 1 showdown.
Baltimore enters the contest with quarterback Lamar Jackson leading a new chapter for the franchise, while Daniel Jones features under center for Indianapolis following their preseason clash in August 2025 at M&T Bank Stadium. Despite entering as massive underdogs seeking to bounce back from a disappointing conclusion to their previous season, Indianapolis aims to counter the near-unanimous expert forecasts and pull off an opening-week surprise.
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