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College football odds, predictions: Ohio State-Indiana, Notre Dame-BYU lead Week 7 slate

Week 7 of college football delivers a slate packed with high-stakes matchups that could reshape playoff aspirations, as six teams ranked in the top 25 square off before the first selection committee rankings drop next month. With preseason predictions now overshadowed by in-season performance—evidenced by struggles from LSU, Texas &M, Michigan, and Penn State—the focus has shifted to which teams can sustain momentum and avoid costly losses.

Among the most critical games, LSU faces Mississippi State in a potential turning point for the Tigers, who must avoid a third SEC loss if they hope to remain in contention for the College Football Playoff. The stakes are equally high for Lane Kiffin, whose first season at LSU hangs in the balance after two defeats to SEC opponents.

Analysts project LSU’s Sam Leavitt, who leads the nation in interceptions, must tighten up to secure a victory, with predictions favoring the Tigers by double digits despite Mississippi State’s competitive edge in recent play.

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