
The Chargers made several roster adjustments ahead of their upcoming matchup against the Bills. Offensive lineman Trey Pipkins III was shut down on the injured reserve list due to a knee problem, ensuring a minimum four-game absence.
Meanwhile, Kayode Awosika is also sidelined with a fibula injury, opening the door for Trevor Penning to step into the starting left guard spot. In response to backup quarterback Trey Lance landing on the injury report with a questionable designation on Friday, the franchise brought up quarterback DJ Uiagalelei onto the active squad to serve behind Justin Herbert if needed.
To address further roster needs, tight end Patrick Herbert and outside linebacker Caleb Murphy were promoted from the practice squad. Patrick Herbert provides depth at a position currently impacted by injuries to David Njoku and Charlie Kolar, while Murphy brings special teams utility.

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