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Arizona Cardinals win first game of Mike LaFleur era

Mike LaFleur started his tenure as head coach of the Arizona Cardinals with an upset victory on Sunday, taking down Jim Harbaugh and the Los Angeles Chargers 26-14. 5 points, the largest spread across the league for the opening slate, yet trailed throughout the entire contest.

Quarterback Jacoby Brissett powered Arizona's offense by completing passes for 277 yards and one touchdown.

The triumph halted a dry spell for the Cardinals, who had not recorded a win since November 3, 2025. In securing the outcome, LaFleur snapped a 53-year franchise drought by becoming the first Cardinals head coach to prevail in his opening game since Don Coryell accomplished the feat in 1973.