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Alabama vs. Tennessee prediction, pick, odds, spread: Rivals Crimson Tide, Vols meet in Knoxville

The SEC’s most storied rivalry takes center stage this weekend as No. 6 Alabama travels to No.

14 Tennessee in a high-stakes clash at Neyland Stadium. The Crimson Tide, seeking to avoid back-to-back regular-season losses for the first time since 2007, arrive in Knoxville following a 20-17 home defeat to Georgia—a setback that narrows their margin for error as they push toward playoff contention.

Alabama’s offense, led by quarterback Keelon Russell (1,599 passing yards, SEC leader), will face its toughest defensive challenge of the season, despite the absence of star receiver Ryan Coleman-Williams due to injury. Tennessee, meanwhile, looks to break a four-game home losing streak against ranked opponents, with their No.

15-ranked rushing attack poised to exploit Alabama’s secondary. The Volunteers, who edged a top-10 Alabama team in 2024, will need a strong performance to capitalize on their recent momentum, including road wins over Kentucky and Mississippi State, and secure their first victory over the Crimson Tide in Knoxville since 2020.

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