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5 Texans to watch vs. the Bills

m. ET kickoff on Sunday.

Both franchises enter the 2026 campaign aiming to build upon postseason runs from the prior season. Houston presents a historically daunting venue for Buffalo, as Josh Allen and his squad have yet to secure a victory in the city.

J. Stroud and wideout Nico Collins as Houston attempts to prove its credentials as a genuine title threat early on.

Defensively, coordinator Matt Burke and edge defender Will Anderson Jr. are preparing the Texans' defensive front to contain Allen.

Anderson has approached this regular-season opener with the intensity of a conference title clash, setting high expectations for the defensive unit. For Buffalo to reverse its past struggles in Houston, the offense will need to hold up against an aggressive pass rush while generating pressure of its own.