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49ers open up as nearly 2-touchdown favorites against the Dolphins

Early betting lines established the San Francisco 49ers as the week's heaviest favorites, giving roughly two touchdowns ahead of their matchup with the Miami Dolphins. San Francisco enters the contest on the heels of a dominant 27-7 triumph over the Los Angeles Rams to open the schedule.

Meanwhile, Miami faces an uphill climb following an 0-1 start under a revamped roster and coaching staff, having dropped their first game 27-13 against the Las Vegas Raiders at Allegiant Stadium. 5-point underdogs.