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2026 NFL Week 2 odds, betting: Full list of Week 2 spreads

Early betting lines are set across the sixteen matchups for the second week of the 2026 NFL campaign following opening-round action. 5-point home favorite against New Orleans.

5 points, with Drew Lock slated to handle signal-calling duties for the road team.

League power rankings saw immediate disruption on the heels of Week 1 outcomes. Arizona, Chicago, the New York Jets, Pittsburgh, Minnesota, Jacksonville, Cincinnati, Philadelphia, Detroit, San Francisco, Buffalo, and Baltimore all secured victories to climb the standings, while Green Bay and New England endured setbacks.