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Week 3 NFL odds, picks, predictions: Computer model backs Lions and 49ers

Ahead of the Week 3 slate, an advanced computer algorithm has wrapped up 10,000 simulations for every upcoming matchup. Among the highlighted games, the Chargers travel to face the Bills as seven-point underdogs, while the Seahawks visit the Commanders with a 7.5-point spread in their favor.

Washington will play without Jayden Daniels due to an elbow injury, whereas Seattle quarterback Sam Darnold enters the contest without an injury tag.

In an unprecedented international fixture, the Cowboys and Ravens will square off in South America for the first NFL matchup held in Rio de Janeiro. Dallas enters the neutral-site contest as the designated home team while conceding 3.5 points to Baltimore.

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