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Week 3 NFL odds, picks, predictions: Computer model backs Lions and 49ers

SportsLine's advanced projection system has processed ten thousand game simulations ahead of Week 3, highlighting several cross-country matchups affected by travel. The Buffalo Bills host the Los Angeles Chargers as seven-point favorites, while the Seattle Seahawks travel to face the Washington Commanders as seven-and-a-half-point favorites with Sam Darnold returning to action and Jayden Daniels sidelined by an elbow injury.

In a historic international contest, the Dallas Cowboys and the Baltimore Ravens will square off in Rio de Janeiro, Brazil, marking the initial NFL fixture held in that city. Dallas enters the neutral-site matchup as the designated home team but remains a three-and-a-half-point underdog according to the latest betting lines.

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