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Week 2 NFL odds, picks, predictions: Computer model backs Seahawks and Buccaneers

An advanced simulation algorithm has completed ten thousand runs for every matchup on the upcoming Week 2 slate, highlighting several heavy favorites as the second week of action approaches. The San Francisco 49ers stand out as the largest favorites of the young season, giving thirteen and a half points to the Miami Dolphins while hosting them at home following a trip to Australia.

Meanwhile, the Los Angeles Rams return from abroad to host the New York Giants as seven and a half point favorites, though they face potential uncertainty with Puka Nacua listed as questionable due to a groin injury.