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Week 2 NFL odds, picks, predictions: Computer model backs Seahawks and Buccaneers

Ahead of Week 2 in the 2026 NFL campaign, attention turns to how the Rams and 49ers will fare back on home soil following their recent trip to Australia. 5 points, marking the largest point spread across the league so far this year.

Los Angeles also faces a significant advantage on Monday night against the Giants, laying 7 points in another primetime slot for New York. Overall, sportsbooks have set lines of at least seven points across six different contests on the slate.

SportsLine's analytical system, which runs 10,000 simulations per fixture, has produced over $7,000 in profit for $100 bettors on top-tier selections since launching, bolstered by a 53-39 record dating back to 2024. Among its key recommendations for the upcoming round, the projection model is backing Seattle to cover the four-point spread on the road against Arizona in a matchup featuring an over/under total of 41.