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Week 2 NFL odds, picks, predictions: Computer model backs Seahawks and Buccaneers

SportsLine has evaluated all Week 2 games across 10,000 simulations, entering the slate with a 53-39 record on its highest-rated selections dating back to 2024 and producing more than $7,000 in profit for hundred-dollar bettors since launching. 5-point favorites against Arizona in a matchup featuring an over/under line of 41 points.

Attention also centers on the Rams and 49ers as they return to domestic action after traveling to Australia in Week 1. 5-point favorite, representing the largest point spread across the league so far, while Los Angeles gives seven points at home against the New York Giants on Monday night.

Those two contests are part of a slate that includes six separate matchups with spreads reaching at least seven points.