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Week 2 NFL odds, picks, predictions: Computer model backs Seahawks and Buccaneers

Following their season openers in Australia, both the Rams and the 49ers return stateside for Week 2 home games. 5-point favorite against the visiting Dolphins, marking the widest spread of the 2026 campaign so far.

Meanwhile, Los Angeles is favored by a full touchdown against the Giants for Monday night action, representing two of six Week 2 showdowns featuring spreads of seven or more points.

SportsLine's predictive algorithm, which runs 10,000 simulations per contest, has generated its selections for the entire slate after producing more than $7,000 for standard $100 bettors on premier picks since launching. 5-point spread as one of its top recommendations.