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Upset alert for NFL Week 2? Why these 5 favorites could easily drop their matchup, including the Ravens

Following a chaotic Week 1 highlighted by the Arizona Cardinals pulling off a shocking upset over the Chargers and the New York Giants toppling the Dallas Cowboys on Monday night, Week 2 presents new vulnerable favorites. 5 points against the Detroit Lions as they debut the new Highmark Stadium, but both squads surrendered at least 30 points in their openers.

Buffalo's run defense remains a significant question mark after conceding three combined touchdowns and 60 rushing yards to David Montgomery alongside 42 yards on nine touches to Woody Marks.

Detroit enters the contest bolstered by Jahmyr Gibbs, who racked up 156 rushing yards, two scores, and forced 10 missed tackles over 34 touches in the opener. Head coach Dan Campbell brings an unblemished 4-0 mark on Thursday Night Football, while quarterback Jared Goff holds a 21-8 record in evening showcase games since 2019.