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NFL Week 1 picks: Experts face off Bills at Texans, Packers-Vikings and more

The 2026 NFL campaign is already underway after Seattle defeated New England in a Wednesday night Super Bowl rematch, followed by San Francisco meeting the Los Angeles Rams in Australia on Thursday. Looking ahead to Sunday's 13-game calendar and beyond, prominent matchups include Josh Allen battling Houston's formidable defense, Green Bay squaring off against Minnesota, and Patrick Mahomes dueling Bo Nix on Monday evening.

5-point road favorite. 1 passer rating since 1970.

In contrast, the hosts face headwinds as Daniel Jones rebounds from an Achilles tear, Alec Pierce works back from ankle surgery, and only Jonathan Taylor appears fully primed against Jesse Minter's defense, yielding projected Baltimore victories of 27-23 and 30-14.

5-point underdog in an opening-week clash with strong wagering trends. The Buccaneers boast the league's top active streak with four consecutive Week 1 straight-up and against-the-spread wins, buoyed by Baker Mayfield securing a three-year contract extension.