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NFL Week 1 odds, predictions, expert picks: Who has edge in Packers-Vikings? Can Giants upset Cowboys?

The 2026 NFL campaign is getting underway with an unusual four-day kickoff schedule. Following a Wednesday Super Bowl rematch and a Thursday contest held in Australia, fans are set for a standard Sunday lineup alongside the traditional Monday night finale.

Betting resources, projections, and staff selections are ready across the slate, highlighting simulations from a proprietary system that has yielded nearly $7,000 in returns for $100 bettors on premier picks since its launch.

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5. Analyst Pete Prisco anticipates a one-sided result and backs the Chargers to cover, expecting head coach Mike McDaniel to debut a run-first attack that enables Justin Herbert to connect on deep play-action attempts while Arizona counters with Jacoby Brissett under center.