NFL

NFL Week 1 odds, predictions, expert picks: Who has edge in Bills-Texans? Can Saints upset Lions?

September 13, 2026

The 2026 NFL campaign begins with action spread across four separate days, featuring a Wednesday Super Bowl rematch and a Thursday game in Australia alongside the standard Sunday schedule and Monday Night Football. m.

5 points. Pittsburgh brings strong home momentum, boasting a 6-2 record against the spread as home favorites across the previous two seasons—a mark matched only by the Jacksonville Jaguars—while Atlanta remains winless in Pittsburgh with an all-time 0-7-1 mark.

Veteran quarterback Aaron Rodgers leads Pittsburgh into the game sporting a career 12-6 Week 1 record featuring 32 touchdowns against 10 interceptions, highlighted by a four-touchdown opener a season ago.

Atlanta enters the contest with Tua Tagovailoa taking the snaps after an offseason signing, despite his preseason struggles and Michael Penix Jr. being sidelined by injury.

Although the Falcons can rely on skill players Bijan Robinson, Drake London, and Kyle Pitts, CBS analyst Jordan Dajani projects the Steelers to easily defeat Atlanta. Predictions and betting insight across the league's slate are derived from the SportsLine Projection Model, which simulates each matchup 10,000 times and has generated nearly $7,000 in earnings on top picks for $100 bettors since its creation, with lines powered by DraftKings Sportsbook.