Photo via CBS Sports

NFL odds: Week 2 parlays featuring favorites, underdogs include Giants vs. Rams, Jaguars vs. Broncos

The second week of the 2026 NFL campaign kicks off on Thursday, September 17, when the Detroit Lions take on the Buffalo Bills. Following unexpected outcomes during the opening slate, handicapper Mike Tierney has crafted separate underdog and favorite multi-leg tickets for the upcoming games.

Tierney enters the week holding a 320-271-16 mark across the previous four seasons, which yielded $1,867 for $100 bettors, bolstered by a 130-101 against-the-spread run over the last two years.

For his recommended favorites parlay, Tierney backs the Dallas Cowboys on the money line against the Washington Commanders, alongside the Los Angeles Chargers to top the Las Vegas Raiders. Dallas looks to avoid falling to 0-2 after dropping their opener to a New York Giants squad led by John Harbaugh.