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Lions-Bills predictions for Thursday, plus NFL Week 2 picks for all 16 games and ranking each starting QB

Week 2 of the NFL calendar begins on Thursday night with a clash between undefeated squads as the Buffalo Bills host the Detroit Lions. Detroit relies heavily on dynamic tailback Jahmyr Gibbs, who racked up 156 rushing yards during the opening contest.

The Lions boast a perfect 11-0 mark historically whenever Gibbs eclipses the century mark on the ground, offering a clear blueprint to control possession against Buffalo's front, which yielded 124 rushing yards in its initial outing.

On the other side, Bills quarterback Josh Allen enters the matchup following a 334-yard passing display versus Houston. He faces a Detroit defensive backfield that surrendered 410 passing yards to Tyler Shough during a Week 1 victory over New Orleans.