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Giants vs. Cowboys picks, NFL predictions: Best bets, odds, betting preview for Sunday Night Football

m. ET kickoff on September 13, 2026.

5 points, having claimed victory in 16 of the prior 18 matchups against their divisional rivals. However, New York took the previous encounter by a 34-17 margin in Week 18 of last year.

Entering his debut year leading the Giants, head coach John Harbaugh carries a personal 12-6 record in season openers from his Baltimore Ravens tenure, aiming to reverse a franchise trend that has seen New York go 2-13 in openers since 2011 while being outscored 89-12 over their last three. The Giants will have wideout Malik Nabers available after being cleared from a knee issue.

Dallas signal-caller Dak Prescott aims to guide the franchise toward ending a three-decade absence from the conference title game. A decade after launching his career in an opening-week defeat against New York, Prescott stands as one of only two NFL quarterbacks to tally 200 or more aerial scores alongside at least 30 ground touchdowns across an opening ten-year span.