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Giants vs. Cowboys picks, NFL predictions: Best bets, odds, betting preview for Sunday Night Football

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5 points, having claimed victory in 16 of the past 18 head-to-head matchups, though New York prevailed 34-17 in their previous encounter during Week 18 of last year. Quarterback Dak Prescott, who debuted a decade ago in an opening-week defeat against the Giants, stands alongside only one other passer in league history with 200-plus passing scores and at least 30 ground touchdowns across his initial 10 campaigns as he attempts to end Dallas's three-decade stretch without an NFC title game trip.

New York has struggled in kickoff games, posting a 2-13 mark in openers since 2011 while being outpaced by an aggregate 89-12 margin across its past three Week 1 outings. Now led by John Harbaugh, who compiled a 12-6 record in season openers while coaching Baltimore, the home underdogs hope to reverse course.