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Giants vs. Cowboys picks, NFL predictions: Best bets, betting preview for Sunday Night Football

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Although the Cowboys have claimed 16 of the past 18 head-to-head matchups, the Giants secured a 34-17 victory in Week 18 of the previous campaign. Dallas quarterback Dak Prescott, who launched his career a decade ago in an opening-week defeat against New York, ranks as one of only two NFL passers to compile a minimum of 200 aerial scores and 30 ground scores throughout their initial 10 campaigns, all while seeking to halt the franchise's three-decade absence from the conference title contest.

New York enters the contest enduring a dismal 2-13 record in season openers dating back to 2011, having been overwhelmed by an aggregate 89-12 margin across the past three openers. 5.

5 combined rushing and receiving yards (-115).