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Clemson vs. Miami odds, picks, predictions, best bets, start time: Betting preview for Week 5 college football

The fourth-ranked Miami Hurricanes put their undefeated record on the line this Saturday as they hit the road to challenge the Clemson Tigers in a pivotal Atlantic Coast Conference matchup. Mario Cristobal leads his squad into this fifth-week showdown following a commanding fifty-two to three victory over Central Michigan, positioning the visitors as substantial favorites by sixteen and a half points.

Meanwhile, Dabo Swinney's Tigers look to defend their home turf at Memorial Stadium after rattling off three consecutive wins, bolstered by the strong play of quarterback Darian Mensah for Miami and freshman signal-caller Tait Reynolds alongside running back Gideon Davidson for Clemson.

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