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Bills vs. Lions odds, predictions, NFL picks, best bets: Betting preview for Thursday Night Football

Week 2 of the NFL season kicks off with a Thursday Night Football showdown featuring two clubs that share the league's top mark since 2023 with the Eagles at 37-15. 5.

The franchise brings strong momentum, having prevailed in five consecutive clashes against Detroit and compiling an 18-2 record across its prior 20 home appearances. Both squads arrive following opening-week victories, as the visiting roster edged the Saints 31-30 in extra time and the hosts secured a 36-31 away triumph against the Texans.

This primetime encounter is their first clash since Buffalo earned a 48-42 shootout victory in 2024. During that previous duel, Josh Allen generated 430 total yards and four touchdowns, whereas Jared Goff threw for 494 yards alongside five passing scores.