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Bills vs. Lions betting guide: Odds, picks, anytime TD scorers for NFL Week 2 Thursday Night Football game

Week 2 of the 2026 NFL campaign gets underway with a Thursday night showdown as the Detroit Lions visit the Buffalo Bills to inaugurate Buffalo's brand-new home venue. 5 points for the contest, with sportsbooks leaning heavily toward the over.

Both franchises began the season with narrow victories that featured porous defensive showings, as each team scored a minimum of 31 points while also surrendering at least 30.

The matchup marks Buffalo's first season following the exit of former head coach Sean McDermott, allowing offensive coordinator Joe Brady greater freedom to unleash the passing attack. Individual wagering options center on marquee contributors such as Bills quarterback Josh Allen and Lions running back Jahmyr Gibbs, whose squads look to navigate the challenges of preparing on short rest.