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2026 Week 3 NFL odds, lines, start times, schedule: Picks, predictions for Rams-Broncos, every other game

The upcoming Week 3 NFL schedule features numerous pivotal matchups as teams navigate injuries and early-season momentum. In injury news, Jaxson Dart faces a season-ending knee problem forcing the Giants to turn to Jameis Winston against the Titans, while Seahawks quarterback Sam Darnold progresses toward a return from a glute issue under coach Mike Macdonald as Commanders quarterback Jayden Daniels deals with an elbow injury.

Meanwhile, the undefeated Bills prepare to host the Chargers following a strong performance led by Josh Allen and James Cook III, contrasting with a struggling Los Angeles squad that recently dropped to 0-2 despite efforts from Justin Herbert and Omarion Hampton.

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