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2026 Week 2 NFL odds, start times, betting lines, spreads: Get Week 2 NFL picks, predictions for every game

Following an action-packed start to the season, the Week 2 NFL slate showcases 16 games, beginning Thursday, Sept. m.

ET when the Bills host the Lions. 5.

5-point underdogs versus the Cowboys. 5-point road favorites over the Falcons.

An intriguing divisional showdown awaits in the NFC North as both Chicago and Minnesota enter 1-0. The Bears generated their fourth-highest single-game offensive output ever with 59 points in their debut, whereas Minnesota rallied late to defeat Green Bay 39-22.

5-point home favorites over the Vikings for the upcoming clash.