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2026 Week 1 NFL predictions, odds, picks, best bets: Model backing Lions, Eagles on Sunday

Week 1 of the 2026 NFL campaign features several prominent Sunday matchups, including an NFC East clash between Philadelphia and Washington. 5 with a game total set at 44.

SportsLine's predictive system anticipates Philadelphia winning 27-18, successfully beating the point spread in 59% of computer runs. Meanwhile, Detroit enters its matchup as a seven-point favorite over New Orleans, who will likely miss Alvin Kamara due to an injured knee, with the simulations favoring the Lions to cover.

5 total points cashing in 59% of trials for the Green Bay and Minnesota divisional showdown. 5 points over the New York Giants.

The underlying model, which tests every game 10,000 times, boasts a 52-37 record on top-tier selections extending back to 2024 and has generated over $7,000 in profits for $100 bettors throughout its existence.