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2026 NFL Week 2 early odds: Bills favored over Lions as Buffalo opens new stadium, Eagles road favorites

Following a wild Week 1 that featured a 96-point shootout between Chicago and Carolina alongside road upsets by Arizona and the New York Jets, attention turns toward early Week 2 betting projections. 5 projected total after both squads surrendered and scored over 30 points previously.

5 over New Orleans and Cleveland respectively. 5 to 7 points in their respective matchups.

5-point edge over Carolina with an unsettled quarterback depth chart after Cooper Rush took snaps in the opener while Tua Tagovailoa and Michael Penix Jr. remained injured.

5 facing the Jets. Buffalo will look to reverse last year's 4-5 home record against the spread in their new venue, anchoring an expansive week of football with five division showdowns and intriguing conference meetings.