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Washington vs USC Prediction, Pick, College Football Odds for Saturday, Oct. 3

The Washington Huskies are preparing to square off against the USC Trojans in Los Angeles on Saturday, October 3, with kickoff scheduled for 7:30 p.m. Eastern time on NBC.

The Trojans enter the matchup as 9.5-point favorites with a moneyline of minus 375, while the visiting Huskies sit as 9.5-point underdogs holding a plus 290 moneyline and a total over-under set at 58.5 points.

Washington faces significant offensive challenges after stumbling against Minnesota, struggling with a ground game where running backs Brian Bonner Jr. and Trey Cooley average two yards or less after first contact alongside quarterback Demond Williams carrying heavily.

Meanwhile, Lincoln Riley's USC squad leans on true freshmen playmakers like Trent Mosley, Mark Bowman, and Kayden Dixon-Wyatt supporting quarterback Jayden Maiava, though the team has experienced defensive regressions under coordinator Gary Patterson.

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